Research Use Only
Research Use Only · Not for medical or veterinary use
NAD+ is not an end in itself, it is the currency the cell pays with. The pool declines with age, and the question of how it can be rebuilt drives much of today's ageing and metabolic research. Nadera supplies NAD+ as research reference material in pre-filled pen format.
Last reviewed:
NAD+ is a cofactor. The NAD+/NADH redox pair carries electrons through glycolysis, the citric acid cycle, and the respiratory chain, driving ATP production, the cell's energy engine. The ratio between the two forms reflects mitochondrial energy status, which makes NAD+ a sensitive marker in metabolic research.
But NAD+ is more than a redox carrier. The same pool is consumed by enzymes: sirtuins (SIRT1–7) use NAD+ to regulate gene expression and ageing, PARP enzymes consume it during DNA repair, and CD38 takes a growing share of the pool with age. It is precisely this dual role, fuel and substrate, that makes NAD+ worth isolating in the laboratory.
Research teams study NAD+ in cell culture models, enzyme kinetics, and mitochondrial function. Results are published in peer-reviewed journals and drive hypotheses forward, they do not in themselves constitute an approved treatment protocol.
NAD+ moves along three interconnected axes. Below are the most relevant for current ageing and metabolic research.
NAD+ is continuously regenerated rather than built from scratch. NMN and NR are direct precursors, and niacin feeds in via a parallel route. NAMPT is the rate-limiting enzyme that converts nicotinamide to NMN. The salvage pathway is the most-studied route for keeping the NAD+ pool topped up.
NAD+ accepts electrons to become NADH in energy-producing reactions, then releases them in the respiratory chain. The NAD+/NADH ratio is a direct readout of the cell's energy balance and mitochondrial function in in vitro models.
NAD+-dependent enzymes linked to ageing, metabolic regulation, and gene expression. They consume NAD+ to work, tying the size of the pool to their activity, a central link in longevity research.
PARP enzymes use NAD+ to repair DNA damage, while CD38 cleaves NAD+ in immune and signalling contexts and consumes a growing share of the pool with age.
It depends on the intended use. The right question is: legal for what purpose?
NAD+ as a research chemical, intended exclusively for in vitro laboratory use (cell and enzyme studies, not use on or in living organisms), is legal to import and purchase within the EU under the regulatory framework that governs non-clinical research substances. It falls outside medicines legislation and anti-doping rules as long as it is sold and purchased for scientific purposes and not for human or veterinary use.
Nadera sells exclusively for research use only (RUO). Our NAD+ is not an approved medicine, not classified as a doping agent, and not intended for human or animal use. Sales and shipment occur from EU stock within EU research frameworks.
If you intend therapeutic use, the medicines authority in your jurisdiction applies, and an approved medicinal product is required. That is a different category, and not what Nadera supplies.
Nadera focuses on a single molecule: NAD+, the dinucleotide coenzyme at the centre of ageing and metabolic research. We supply it in pre-filled pen format, ready to use and ready for laboratory handling, with a Certificate of Analysis (CoA), clear specification, and EU delivery directly from our own stock. NAD+ is not well absorbed orally, so the pen delivers a controlled dose directly, the potent route compared with capsules.
We do not sell an assortment of ten substances with unclear provenance. We supply one molecule we can stand behind, with documentation that holds up in a research environment.
Weighing up formats? Read our NAD+ pen vs capsules comparison for bioavailability, dose control, and price per mg before you choose.
All products are sold strictly for in vitro laboratory purposes. Not for human or veterinary use.
Order NAD+ for research
High purity, CoA-verified, EU delivery. Strictly for in vitro laboratory use.
